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Indinavir answers (191)

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Q: 

What Is indinavir?

A: indinavir is an antiretroviral drug used to treat human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). This medication is of a type called a protease inhibitor, which means that it inhibits the activity of a viral enzyme called a protease. indinavir is used in conjunction with other antiretroviral drugs in a type of therapy called highly active antiretroviral therapy (HAART). In addition to being used as an HIV treatment, HAART is used as a preventative measure for healthcare workers who are at risk of HIV exposure. Proteases are enzymes that break down proteins, and they are naturally present in all life forms, including plants and single-cell organisms. For retroviruses such as the human immunodeficiency...


Q: 

indinavir sulfate

A: Response from Dr. Young Thanks for your post. indinavir (Crixivan) can be dosed either way-- without ritonavir (Norvir) boosting, the medication is dosed every 8 hours, fasting. indinavir should not be administered twice daily without ritonavir. With ritonavir, the medication can be dosed twice-daily (800 mg with 100 mg ritonavir) and without meal restrictions. Hope this helps, BY...


Q: 

indinavir - Can it be used as post sexual exposure prophylaxis?

A: No. indinavir does not prevent the spread of HIV to others through sexual contact. It is used in combination to help treat HIV infection. It also lowers the risk of getting HIV complications (such as new infections, cancer). indinavir belongs to a class of drugs known as protease inhibitors. See: http://www.drugs.com/cdi/indinavir.html...
Q: 

Question about indinavir twice a day?

A: Response from Dr. Gallant Using indinavir twice a day is not currently recommended, although it is being studied. In a small trial, doses of 1000 and 1200 mg twice daily looked as safe and effective as 800 mg every 8 hours, but we''ll need the results of the larger trial currently in progress before we can recommend that people take that dose. If one WERE to take such a dose, it would be just as necessary to drink lots of fluids (at least 1.5 liters)....


Q: 

Delavirdine interactions with indinavir and other antiretrovirals.

A: Response from Dr. Cohen Yup. Very clear. Hope the answer is equally lucid. Yes -- delavirdine (for simplicity I''ll abbreviate it DLV) does have similar effects on the p450 system as does ritonavir. Not as potent but similar. So yes you can dose reduce the IDV to 600 TID and do well. (not sure why you also have dose reduced the d4T and ddI but I''ll leave that one for now...) The drug interaction work that was done is often summarized in the PDR -- the package insert that you can get from any pharmacist when the give you your month''s supply of meds. In all of that fine print and tiny writing are the details -- with perhaps some charts -- of many of the studies done. In addition, there are summaries of drug drug interactions on some web sites -- you can start with the company that owns...


Q: 

indinavir, NORVIR, LAMIVUDINA

A: Response from Dr. Wohl I suspect your brother is on one more additional drug (probably zidovudine or stavudine) along with his indinavir, ritonavir and lamivudine. If he is not, he should be. This is an older combination of drugs not used much in the US but it should work to reduce the level of virus and allow some restoration of the CD4 cells. A major problem with this combination is kidney stones. Have him drink a lot of water every day. I do not know what other HIV meds are available in Bolivia that may be better tolerated. There is no need for T-20 at this point. This is a medication best reserved for when there are limited alternative options. If your brother does acheive an increase in his CD4 cell count on his current medications, this will demonstrate their...


Q: 

indinavir intensification

A: Response from Dr. Stryker Nope -- I think you are probably right on the money. Your partner is risking it all by taking Crix with food and/or skipping doses. Why go through the hassle of taking meds, and possible side effects, if you don''t do everything possible to get the full benefit? Even though his numbers are good now, three year is a small time compared to the rest of his life. When someone is at risk of failure from ''non-compliance'', some kind of change is needed. A couple of options. There is a lot of variability in individual patient Crix metabolism, so it could be that your guy is lucky and maintains very high levels despite his cavalier attitude. A trough drug level (in the AM before his first dose) could help figure this out. If he does this, it would be important to...


Q: 

Afiran Desperate for Aswers

A: Response from Dr. Wohl I am sorry you have had so much trouble - especially from my brothers and sisters in the medical profession. If you were taking nevirapine, zidovudine and the lamivudine once a day for a prolonged period (more than 1-2 weeks), I would be concerned your virus might be resistant to the nevirapine. Otherwise, I think this combination is very good for you, if taken twice a day as recommended. indinavir three times a day on an empty stomach is difficult. I would consider trying the nevirapine, zidovudine and the lamivudine again and having your CD4 cell count checked every month for about 4 months to make certain it is working. IF there is any indication it is not working an alternative, at least here in the US, would be something like tenofovir...


Q: 

Pep Questions

A: Response from Dr. Young It''s ok to take your medications as you''ve cited. Both drugs are better tolerated if taken with food. There shouldn''t be any problem in switching from indinavir to Kaletra, indeed, the later is probably more potent. Good luck, BY...


 
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