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Proton pump inhibitor answers (918)

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What Is a proton pump inhibitor?

A: A proton pump inhibitor is a type of stomach acid blocker known as an anti-ulcer drug. It works by preventing acid production in the stomach. There are several kinds of proton pump inhibitor available, but they all work in the same way. The differences are the ways they are broken down by the body and their drug interactions. Antacids work by coating the stomach and neutralizing the acid produced. A proton pump inhibitor keeps the stomach from producing acid in the first place. This offers better, longer-lasting relief from acid symptoms. Conditions usually treated...


What Are proton pump inhibitors?

A: proton pump inhibitors (PPIs) may also be called antacids, though they are a specific type of antacid that aids in blocking stomach cells from producing acid in the form of hydrogen ions. Not all antacids are the same, and PPIs are often compared to another type of acid reducer called the H2 blocker. H2 blockers interfere with a different mechanism and reduce histamine response that signals the stomach to produce more acid. H2 blockers are usually more effective short-term, and shorter acting, but they need to be taken with greater frequency. PPIs, in contrast, tend to work more effectively for longer periods of time, but may need to be taken for several days before they begin to work well. Either an H2 blocker...


Can proton pump inhibitors interfere with nutrient absorption?

A: proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available today. The medication you are taking, Lomex-T (omeprazole), is manufactured by Actavis. It is recommended that this medication be taken whole once daily in the morning with half a glass of water. As with most medications, best results are obtained either one hour before or two hours after food. More information may be obtained at the Web site: http://www.everydayhealth.com/drugs/omeprazole. I could find no indications of blocked or reduced absorption of nutrients by this medication....


How safe is it take proton pump inhibitors for many years?

A: As with any medication, there are possible side effects associated with taking Kapidex (dexlansoprazole). When choosing a medication therapy, one must weigh the risks and the benefits associated with taking a product. The following are the most common adverse reactions reported while taking Kapidex: diarrhea, abdominal pain, flatulence, nausea, vomiting, and upper respiratory tract infection. There have been reports and thoughts that proton pump inhibitors can have a potential for serious side effects. As always, talk to your health care provider regarding questions you have about your medications. Attached is a link to additional information provided by Everyday Health regarding GERD:...


do proton pump inhibitors affect the effectiveness of birth control pills?

A: Hi there. Welcome to the forum! There are some drugs which can interact with oral contraceptive pills like -smoking, griseofulvin, phenobarbital, antibiotics etc. proton pump inhibitors don''t interact with birthcontrol pills. Please keep us posted for any further queries. Hope this helps you. Take care and regards!...

Can a proton pump inhibitor help prevent cancer in patients with Barrett''s Esophagus? Your podcast was very informative, but this wasn''t mentioned.

A: This is an excellent question without a clear answer. Some data does suggest that PPIs (proton pump inhibitors) may lower the risk of progression to esophageal cancer, but the data is not definitive. The other reason to use a PPI is for treatment of acid reflux. Some patients with Barrett''s never notice any acid reflux, but we believe it could be the cause of the Barrett''s in the first place. We tend to continue PPIs to prevent further acid reflux and possible increase in the Barrett''s. The FDA has recently updated the information about PPIs with concerns about osteoporosis and other issues. However for most people the benefit outweighs the risk of use. I do urge my patients on PPIs to have their vitamin D levels...


Does clopidogrel interact with proton pump inhibitors?

A: The SPC for clopidogrel [1] makes no mention of interactions.  Similarly, the FDA monograph (via drugs.com) also fails to mention an interaction [2]   However, a 2009 article in the CMAJ [3] “A population-based study of the drug interaction between proton pump inhibitors and clopidogrel” reported the following:   “Results: Among 13 636 patients prescribed clopidogrel following acute myocardial infarction, we identified 734 cases readmitted with myocardial infarction and 2057 controls. After extensive multivariable adjustment, current use of proton pump inhibitors was associated with an increased risk of...

When should a proton pump inhibitor not be used?

A: On One Hand: proton pump inhibitor UseA proton pump inhibitor (PPI) decreases gastric acid secretion by irreversibly blocking the H+/K+ ATPase (gastric proton pump) of the gastric parietal cell. PPIs such as Prilosec (omeprazole), Prevacid (lansoprazole), protonix (pantoprazole) and Nexium (esomeprazole) are more effective than H2 antagonists (ranitidine). The PPIs are used for dyspepsia, gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), Barrett''s esophagus, stress gastritis prevention, gastrinomas and Zollinger-Ellison syndrome....


What is the evidence for the link between proton pump inhibitor usage and the development of Clostridium Difficile infection?

A: In 2005 Bandolier gave the following clinical bottom line [1]:   "Reduction of PPI use may be an additional strategy to reduce the incidence of this infection."   Also in 2005 a JAMA article [2] concluded:    "The use of acid-suppressive therapy, particularly proton pump inhibitors, is associated with an increased risk of community-acquired C difficile. The unexpected increase in risk with nonsteroidal anti-inflammatory drug use should be investigated further."   In 2006 a CMAJ article [3] reported:   "proton pump inhibitor use was associated with an increased risk of community-acquired...

What are the effects of long-term use of proton pump inhibitors?

A: In May 2010, the U.S. Food and Drug Administration (FDA) released a safety announcement about an increased risk of hip, wrist, and spine fractures associated with the use of proton pump inhibitors (PPIs), like Prevacid (lansoprazole). The FDA is requiring labeling changes to include warning information on this issue. The FDA''s decision to require manufacturers to change labeling is based on its review of several epidemiological studies that identified the increased risk of fractures. Some of these studies suggest that the risk is greatest in patients receiving high doses of PPIs or who have been taking a PPI for greater than one year. However, there are limitations to these studies or reasons that make it difficult...

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